Low-temperature approach to highly emissive copper indium sulfide colloidal nanocrystals and their bioimaging applications.
Identifieur interne : 000563 ( Main/Exploration ); précédent : 000562; suivant : 000564Low-temperature approach to highly emissive copper indium sulfide colloidal nanocrystals and their bioimaging applications.
Auteurs : RBID : pubmed:23486927English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Colloids, Copper, Indium, Sulfides.
- chemistry : Glioblastoma, Nanoparticles.
- instrumentation : Molecular Imaging.
- methods : Molecular Imaging.
- Animals, Cell Line, Tumor, Cold Temperature, Humans, Male, Mice, Mice, Nude.
Abstract
We report our newly developed low-temperature synthesis of colloidal photoluminescent (PL) CuInS2 nanocrystals (NCs) and their in vitro and in vivo imaging applications. With diphenylphosphine sulphide (SDPP) as a S precursor made from elemental S and diphenylphosphine, this is a noninjection based approach in 1-dodecanethiol (DDT) with excellent synthetic reproducibility and large-scale capability. For a typical synthesis with copper iodide (CuI) as a Cu source and indium acetate (In(OAc)3) as an In source, the growth temperature was as low as 160 °C and the feed molar ratios were 1Cu-to-1In-to-4S. Amazingly, the resulting CuInS2 NCs in toluene exhibit quantum yield (QY) of ~23% with photoemission peaking at ~760 nm and full width at half maximum (FWHM) of ~140 nm. With a mean size of ~3.4 nm (measured from the vertices to the bases of the pyramids), they are pyramidal in shape with a crystal structure of tetragonal chalcopyrite. In situ (31)P NMR (monitored from 30 °C to 100 °C) and in situ absorption at 80 °C suggested that the Cu precursor should be less reactive toward SDPP than the In precursor. For our in vitro and in vivo imaging applications, CuInS2/ZnS core-shell QDs were synthesized; afterwards, dihydrolipoic acid (DHLA) or 11-mercaptoundecanoic acid (MUA) were used for ligand exchange and then bio-conjugation was performed. Two single-domain antibodies (sdAbs) were used. One was 2A3 for in vitro imaging of BxPC3 pancreatic cancer cells. The other was EG2 for in vivo imaging of a Glioblastoma U87MG brain tumour model. The bioimaging data illustrate that the CuInS2 NCs from our SDPP-based low-temperature noninjection approach are good quality.
DOI: 10.1021/am302951k
PubMed: 23486927
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Low-temperature approach to highly emissive copper indium sulfide colloidal nanocrystals and their bioimaging applications.</title><author><name sortKey="Yu, Kui" uniqKey="Yu K">Kui Yu</name><affiliation wicri:level="1"><nlm:affiliation>Emerging Technologies, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada. kui.yu@nrc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Emerging Technologies, National Research Council of Canada, Ottawa, Ontario, K1A 0R6</wicri:regionArea></affiliation></author><author><name sortKey="Ng, Peter" uniqKey="Ng P">Peter Ng</name></author><author><name sortKey="Ouyang, Jianying" uniqKey="Ouyang J">Jianying Ouyang</name></author><author><name sortKey="Zaman, Md Badruz" uniqKey="Zaman M">Md Badruz Zaman</name></author><author><name sortKey="Abulrob, Abedelnasser" uniqKey="Abulrob A">Abedelnasser Abulrob</name></author><author><name sortKey="Baral, Toya Nath" uniqKey="Baral T">Toya Nath Baral</name></author><author><name sortKey="Fatehi, Dorothy" uniqKey="Fatehi D">Dorothy Fatehi</name></author><author><name sortKey="Jakubek, Zygmunt J" uniqKey="Jakubek Z">Zygmunt J Jakubek</name></author><author><name sortKey="Kingston, David" uniqKey="Kingston D">David Kingston</name></author><author><name sortKey="Wu, Xiaohua" uniqKey="Wu X">Xiaohua Wu</name></author><author><name sortKey="Liu, Xiangyang" uniqKey="Liu X">Xiangyang Liu</name></author><author><name sortKey="Hebert, Charlie" uniqKey="Hebert C">Charlie Hebert</name></author><author><name sortKey="Leek, Donald M" uniqKey="Leek D">Donald M Leek</name></author><author><name sortKey="Whitfield, Dennis M" uniqKey="Whitfield D">Dennis M Whitfield</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.1021/am302951k</idno><idno type="RBID">pubmed:23486927</idno><idno type="pmid">23486927</idno><idno type="wicri:Area/Main/Corpus">000743</idno><idno type="wicri:Area/Main/Curation">000743</idno><idno type="wicri:Area/Main/Exploration">000563</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Cold Temperature</term><term>Colloids (chemistry)</term><term>Copper (chemistry)</term><term>Glioblastoma (chemistry)</term><term>Humans</term><term>Indium (chemistry)</term><term>Male</term><term>Mice</term><term>Mice, Nude</term><term>Molecular Imaging (instrumentation)</term><term>Molecular Imaging (methods)</term><term>Nanoparticles (chemistry)</term><term>Sulfides (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Colloids</term><term>Copper</term><term>Indium</term><term>Sulfides</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Glioblastoma</term><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Molecular Imaging</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Imaging</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Cold Temperature</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Nude</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report our newly developed low-temperature synthesis of colloidal photoluminescent (PL) CuInS2 nanocrystals (NCs) and their in vitro and in vivo imaging applications. With diphenylphosphine sulphide (SDPP) as a S precursor made from elemental S and diphenylphosphine, this is a noninjection based approach in 1-dodecanethiol (DDT) with excellent synthetic reproducibility and large-scale capability. For a typical synthesis with copper iodide (CuI) as a Cu source and indium acetate (In(OAc)3) as an In source, the growth temperature was as low as 160 °C and the feed molar ratios were 1Cu-to-1In-to-4S. Amazingly, the resulting CuInS2 NCs in toluene exhibit quantum yield (QY) of ~23% with photoemission peaking at ~760 nm and full width at half maximum (FWHM) of ~140 nm. With a mean size of ~3.4 nm (measured from the vertices to the bases of the pyramids), they are pyramidal in shape with a crystal structure of tetragonal chalcopyrite. In situ (31)P NMR (monitored from 30 °C to 100 °C) and in situ absorption at 80 °C suggested that the Cu precursor should be less reactive toward SDPP than the In precursor. For our in vitro and in vivo imaging applications, CuInS2/ZnS core-shell QDs were synthesized; afterwards, dihydrolipoic acid (DHLA) or 11-mercaptoundecanoic acid (MUA) were used for ligand exchange and then bio-conjugation was performed. Two single-domain antibodies (sdAbs) were used. One was 2A3 for in vitro imaging of BxPC3 pancreatic cancer cells. The other was EG2 for in vivo imaging of a Glioblastoma U87MG brain tumour model. The bioimaging data illustrate that the CuInS2 NCs from our SDPP-based low-temperature noninjection approach are good quality.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23486927</PMID><DateCreated><Year>2013</Year><Month>04</Month><Day>24</Day></DateCreated><DateCompleted><Year>2013</Year><Month>10</Month><Day>25</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1944-8252</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>8</Issue><PubDate><Year>2013</Year><Month>Apr</Month><Day>24</Day></PubDate></JournalIssue><Title>ACS applied materials & interfaces</Title><ISOAbbreviation>ACS Appl Mater Interfaces</ISOAbbreviation></Journal><ArticleTitle>Low-temperature approach to highly emissive copper indium sulfide colloidal nanocrystals and their bioimaging applications.</ArticleTitle><Pagination><MedlinePgn>2870-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/am302951k</ELocationID><Abstract><AbstractText>We report our newly developed low-temperature synthesis of colloidal photoluminescent (PL) CuInS2 nanocrystals (NCs) and their in vitro and in vivo imaging applications. With diphenylphosphine sulphide (SDPP) as a S precursor made from elemental S and diphenylphosphine, this is a noninjection based approach in 1-dodecanethiol (DDT) with excellent synthetic reproducibility and large-scale capability. For a typical synthesis with copper iodide (CuI) as a Cu source and indium acetate (In(OAc)3) as an In source, the growth temperature was as low as 160 °C and the feed molar ratios were 1Cu-to-1In-to-4S. Amazingly, the resulting CuInS2 NCs in toluene exhibit quantum yield (QY) of ~23% with photoemission peaking at ~760 nm and full width at half maximum (FWHM) of ~140 nm. With a mean size of ~3.4 nm (measured from the vertices to the bases of the pyramids), they are pyramidal in shape with a crystal structure of tetragonal chalcopyrite. In situ (31)P NMR (monitored from 30 °C to 100 °C) and in situ absorption at 80 °C suggested that the Cu precursor should be less reactive toward SDPP than the In precursor. For our in vitro and in vivo imaging applications, CuInS2/ZnS core-shell QDs were synthesized; afterwards, dihydrolipoic acid (DHLA) or 11-mercaptoundecanoic acid (MUA) were used for ligand exchange and then bio-conjugation was performed. Two single-domain antibodies (sdAbs) were used. One was 2A3 for in vitro imaging of BxPC3 pancreatic cancer cells. The other was EG2 for in vivo imaging of a Glioblastoma U87MG brain tumour model. The bioimaging data illustrate that the CuInS2 NCs from our SDPP-based low-temperature noninjection approach are good quality.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Kui</ForeName><Initials>K</Initials><Affiliation>Emerging Technologies, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada. kui.yu@nrc.ca</Affiliation></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Ouyang</LastName><ForeName>Jianying</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Zaman</LastName><ForeName>Md Badruz</ForeName><Initials>MB</Initials></Author><Author ValidYN="Y"><LastName>Abulrob</LastName><ForeName>Abedelnasser</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Baral</LastName><ForeName>Toya Nath</ForeName><Initials>TN</Initials></Author><Author ValidYN="Y"><LastName>Fatehi</LastName><ForeName>Dorothy</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Jakubek</LastName><ForeName>Zygmunt J</ForeName><Initials>ZJ</Initials></Author><Author ValidYN="Y"><LastName>Kingston</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xiaohua</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Xiangyang</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Hebert</LastName><ForeName>Charlie</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Leek</LastName><ForeName>Donald M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Whitfield</LastName><ForeName>Dennis M</ForeName><Initials>DM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>03</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Appl Mater Interfaces</MedlineTA><NlmUniqueID>101504991</NlmUniqueID><ISSNLinking>1944-8244</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Colloids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Sulfides</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical><Chemical><RegistryNumber>789U1901C5</RegistryNumber><NameOfSubstance>Copper</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cold Temperature</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Colloids</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Copper</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Glioblastoma</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, Nude</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Molecular Imaging</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Nanoparticles</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sulfides</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>3</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>3</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>3</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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